Khetha Thina
I-JDK iphethe izixhobo zokuvelisa iklasi yokuqala kunye nezixhobo zokulawula uMgangatho, oqinisekisa ukunikezelwa okuzinzile kwe-API intermediates.Iqela lobuchwephesha liqinisekisa iR&D ngemveliso.Ngokuchasene nazo zombini, sikhangela i-CMO kunye ne-CDMO kwimarike yasekhaya neyamanye amazwe.
Ingcaciso yeMveliso
Kwisiseko sayo, i-17-amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid i-compound eyinkimbinkimbi enobuchule obukhulu kwizicelo ezahlukeneyo.Ubume bayo bemolekyuli kunye nokudityaniswa okukodwa kwezinto kuyenza ibe yi-asethi exabisekileyo kuphuhliso lwamachiza, i-biochemistry kunye neenzame ezinxulumene nenzululwazi.
Enye yezinto eziphambili zale mveliso kukuguquguquka kwayo.I-17-Amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid ingasetyenziselwa njengebhloko yokwakha ekuhlanganiseni iamolekyu ezahlukeneyo ze-bioactive, ezifana ne-peptides kunye neeprotheni.Amaqela ayo asebenzayo kunye nokulandelelana kwe-amino acid kwenza ukuguqulwa okusebenzayo kunye nokuchanekileyo, ukuqinisekisa umgangatho ophezulu wokulawula kunye neenkcukacha ezithile kuyilo lwamachiza.
Abaphandi kunye nososayensi kwiinkalo zonyango kunye nokufunyanwa kweziyobisi baya kuzuza kakhulu ngokubandakanya le mveliso kuphando lwabo.Izicelo ezinokwenzeka zisuka kwiinkqubo ezichongiweyo zokuhanjiswa kweziyobisi ukuya kuphuhliso lwenoveli yeearhente zonyango.Ngokusebenzisa iipropathi ezikhethekileyo ze-17-amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid, iinkampani zoxubo-mayeza zinokuvelisa izinto ezintsha kwaye zenze unyango oluyimpumelelo kwizifo ezahlukeneyo.
Ukongezelela, ukuqina kwemveliso kuqinisekisa ukuzinza nokuthembeka phantsi kweemeko ezahlukeneyo zokulinga.Ubunzima bayo bemolekyuli kunye nokuqulunqwa kuye kwayilwa ngononophelo ukubonelela nge-solubility efanelekileyo, ukuvumela ukudibanisa lula kwiiprothokholi zokulinga.Ukongeza, ukucoceka kwemveliso kunye nokungaguquguquki kuqinisekisa iziphumo ezinokuphinda ziphinde ziphinde ziphinde zivele, nto leyo eyenza ibe sisixhobo esiyimfuneko kwiziphumo zophando ezithembekileyo.
Xa kuziwa kukhuseleko, sithatha zonke izilumkiso zokuqinisekisa ukuba i-17-amino-10-oxy-3,6,12,15-tetraoxa-9-azaheptadecanoic acid ihlangabezana nemigangatho ephezulu yomgangatho.Amanyathelo okulawula umgangatho ongqongqo athathwa kuyo yonke inkqubo yokuvelisa ukuqinisekisa ukungabikho kokungcola okanye ukungcola.
![I-Tofacitinib Intermediate (2R, 3R) -2,3-bis [(4-methylbenzoyl) oxy] succinic acid kunye (3R, 4R) - N, 4-dimethyl-1- (phenylmethyl) -3-piperidine amine CAS No. 477600 -71-8](http://cdn.globalso.com/jdkhc/2R-3R-23-bis-4-methylbenzoyl-oxy-succinic-acid-and-3R-4R-N-4-dimethyl-1-phenylmethyl-3-piperidine-amine.jpg)
