Inkcazo
I-Vorolazan fumarate isebenza ngokuthintela impompo yeproton esiswini, ngaloo ndlela inciphisa ukuveliswa kwe-asidi yesisu.Ngokungafaniyo neproton pump inhibitors (PPIs) yemveli, iVorolazan fumarate ibonise ukuqala ngokukhawuleza kwesenzo kunye noxinzelelo oluqhubekayo lwe-asidi, iyenza ibe lukhetho olusebenzayo lonyango kwizigulana eziphendule kakubi kunyango lwangoku.
Enye yeenzuzo ezinkulu zeVorolazan fumarate kukukwazi ukoyisa imida yamanye amachiza okwehlisa iasidi.Indlela yayo ekhethekileyo yesenzo inqanda ukukhuselwa kwe-asidi ngokuqhubekayo kwaye ixesha elide, okukhokelela ekulawuleni ngcono iimpawu kunye nokuthintela ukuphindaphinda kwezilonda.Ukongeza, iVorolazan fumarate ibonakaliswe ukuba inamandla asezantsi entsebenziswano yamachiza, iyenza ibe lukhetho olukhuselekileyo kwizigulana ezinezifo ezininzi ezidinga iirejimeni zamachiza ezinzima.
Kwizifundo zeklinikhi, uFumarate Vorolazan ubonise ukusebenza kakuhle xa kuthelekiswa neePPI ezikhoyo, ngokuqala ngokukhawuleza kwesenzo kunye noxinzelelo oluphezulu lwe-asidi.Oku kuthetha ukuba izigulana zinokufumana isiqabu ngokukhawuleza kwiimpawu ezifana nesitshisa kunye ne-reflux, ukuphucula umgangatho wobomi kunye nokunciphisa imfuno yamayeza okuhlangula.
Khetha Thina
I-JDK iphethe izixhobo zokuvelisa iklasi yokuqala kunye nezixhobo zokulawula uMgangatho, oqinisekisa ukunikezelwa okuzinzile kwe-API intermediates.Iqela lobuchwephesha liqinisekisa iR&D ngemveliso.Ngokuchasene nazo zombini, sikhangela i-CMO kunye ne-CDMO kwimarike yasekhaya neyamanye amazwe.
