Khetha Thina
I-JDK iphethe izixhobo zokuvelisa iklasi yokuqala kunye nezixhobo zokulawula uMgangatho, oqinisekisa ukunikezelwa okuzinzile kwe-API intermediates.Iqela lobuchwephesha liqinisekisa iR&D ngemveliso.Ngokuchasene nazo zombini, sikhangela i-CMO kunye ne-CDMO kwimarike yasekhaya neyamanye amazwe.
Ingcaciso yeMveliso
I-N-Acetyl-3- (3,5-difluorophenyl) -DL-alanine, okanye ngokulula i-N-acetyl-3-DFA-DL-alanine, i-synthetic amino acid derivative.Idibanisa i-acetyl, i-alanine kunye nezangqa ze-difluorobenzene.Olu lwakhiwo lukhethekileyo lwemolekyuli lunika iipropati ezikhethekileyo, nto leyo eyenza ibe sisixhobo esixabisekileyo kuphando lwamayeza kunye neekhemikhali.
Enye yeempawu eziphawulekayo ze-N-acetyl-3-DFA-DL-alanine kukukwazi ukuvimbela i-enzyme ethile emzimbeni womntu.Esi sithintelo sinokuba nempembelelo enkulu kunyango, ngakumbi kuphuhliso lonyango olutsha lwezifo ezichatshazelwa zii-enzyme ezichongiweyo.Ngaphaya koko, ukukwazi kwayo ukumodareyitha iinkqubo ezithile zebhayoloji ngokunxibelelana ngokukhethayo kunye nezamkeli ezithile kuyenza ibe yimpahla exabisekileyo kufundo lweendlela ezahlukeneyo zomzimba.
Enye into enyanzelisayo yale khompawundi yinto enokubakho njengebhloko yokwakha ukuhlanganiswa kwezinye iiamolekyu ezinzima.Ukuguquguquka kwayo kuvumela ukudalwa kwezinto ezintsha zeekhemikhali, okwenza kube luncedo kakhulu kwi-chemistry yamayeza kunye nokufunyanwa kweziyobisi.Abaphandi banokusebenzisa iipropathi ezizodwa ze-N-acetyl-3-DFA-DL-alanine ukwenza abaviwa amayeza anoveli kunye neeprofayili eziphuculweyo ze-pharmacological.
Ukongeza, i-N-acetyl-3-DFA-DL-alanine ine-solubility egqwesileyo kwi-solvents eyahlukeneyo ye-polar kunye ne-non-polar, iququzelela ukusetyenziswa kwayo kwiinkqubo ezahlukeneyo zokulinga.Ukuzinza kwayo phantsi kweemeko ezahlukeneyo kuqinisekisa iziphumo ezithembekileyo, ezivumela abaphandi ukuba benze iimvavanyo ezicokisekileyo kwaye bafumane idatha echanekileyo.
Ukucoceka kunye nomgangatho we-N-Acetyl-3-DFA-DL-Alanine kubaluleke kakhulu, kwaye njengomthengisi ozidlayo, siqinisekisa ukuba iimveliso zethu zihlangabezana nemigangatho ephezulu.I-N-Acetyl-3-DFA-DL-Alanine yethu idityaniswe kusetyenziswa iteknoloji yezobugcisa kunye nemilinganiselo engqongqo yokulawula umgangatho wokuqinisekisa ukuhambelana nokuthembeka kwibhetshi nganye.
