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iimveliso

I-Tofacitinib Intermediate (2R, 3R) -2,3-bis [(4-methylbenzoyl) oxy] succinic acid kunye (3R, 4R) - N, 4-dimethyl-1- (phenylmethyl) -3-piperidine amine CAS No. 477600 -71-8

Inkcazelo emfutshane:

Ifomula yemolekyuli:I-C48H62N4O8
Ubunzima beMolekyuli:823.028


Iinkcukacha zeMveliso

Iithegi zeMveliso

Inkcazo

I-tofacitinib yethu ephakathi ibaluleke kakhulu kwinkqubo yokwenziwa kwe-tofacitinib, ichiza elaziwayo elisetyenziselwa ukunyanga iintlobo ezithile ze-arthritis.Esi siphakathi sidlala indima ebalulekileyo kwimveliso ye-tofacitinib, igalelo ekusebenzeni kwayo kunye nomgangatho.Nge (2R, 3R) -2,3-bis [(4-methylbenzoyl) oxy]succinic acid kunye (3R,4R)-N,4-dimethyl-1- (phenylmethyl)- Inhlanganisela echanekileyo ye-3-piperidinamines, yethu imveliso iqinisekisa ukuhlanganiswa komgangatho ophezulu we-tofacitinib odibana kunye nokugqithisa imigangatho yoshishino.

Ifomula yemolekyuli kunye nobunzima be-tofacitinib yethu ephakathi ibonisa ubunyulu kunye namandla, oko kuyenza ibe yinxalenye ethembekileyo yenkqubo yokuvelisa amayeza.Ngezithako zayo ezilinganiswe ngononophelo, le ndawo iphakathi iqinisekisa ukuhambelana kunye nokusebenza kwemveliso yokugqibela, i-tofacitinib.Iipropathi zayo zeemolekyuli zikwanegalelo kuzinzo jikelele lwe-tofacitinib kunye nobomi beshelufa, ukuqinisekisa ukuba ihlala isebenza kwaye ithembekile kwixesha elide.

Khetha Thina

I-JDK iphethe izixhobo zokuvelisa iklasi yokuqala kunye nezixhobo zokulawula uMgangatho, oqinisekisa ukunikezelwa okuzinzile kwe-API intermediates.Iqela lobuchwephesha liqinisekisa iR&D ngemveliso.Ngokuchasene nazo zombini, sikhangela i-CMO kunye ne-CDMO kwimarike yasekhaya neyamanye amazwe.


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