Inkcazo
I-Topirastat ephakathi kwe-2-cyanoisonicotinic acid, i-CAS No. 161233-97-2.Le mveliso iyaziwa nangamanye amagama: i-2-cyanopyridine-4-carboxylic acid, i-2-cyano-4-pyridinecarboxylic acid, kunye ne-4-pyridinecarboxylic acid, i-2-cyano-.Ifomula ye-molecular yale ngqungquthela ephakathi yi-C7H4N2O2 kunye nobunzima be-molecular yi-148.1189.Iyinxalenye ebalulekileyo kwi-synthesis ye-topirastat (iyeza elisetyenziselwa ukunyanga i-hyperuricemia kwizigulane ze-gout).
I-2-Cyanoisonicotinic acid idlala indima ebalulekileyo ekuveliseni i-topirastat, esebenza ngokuthintela i-xanthine oxidase, i-enzyme ebandakanyeka kwimveliso ye-uric acid.Ngenxa yoko, amanqanaba e-uric acid egazini ayancipha, athomalalisa iimpawu zezigulane zegawuthi.Le ngqungquthela ephakathi iyisithako esibalulekileyo kwinkqubo yokuvelisa i-topirastat, eyenza ibe yinxalenye ebalulekileyo yoshishino lwamayeza.
Khetha Thina
I-JDK iphethe izixhobo zokuvelisa iklasi yokuqala kunye nezixhobo zokulawula uMgangatho, oqinisekisa ukunikezelwa okuzinzile kwe-API intermediates.Iqela lobuchwephesha liqinisekisa iR&D ngemveliso.Ngokuchasene nazo zombini, sikhangela i-CMO kunye ne-CDMO kwimarike yasekhaya neyamanye amazwe.
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